Cenforce 100 should be taken only once within a 24-hour period. Taking more than one dose in a day can increase the risk of serious side effects such as low blood pressure, prolonged erections (priapism), or cardiovascular issues. The medication typically remains effective for 4 to 6 hours, depending on individual factors like metabolism, age, and overall health. If the effects wear off and you're considering another dose, you must wait at least 24 hours unless your doctor advises otherwise. Always follow your healthcare provider’s guidance to ensure safe and effective use of Cenforce 100.